AbbVie prior sponsor Abbott Source. To assess the safety tolerability and pharmacokinetics of ABT-981 in.
Lutikizumab ABT 981 a dual-variable domain immunoglobulin that inhibits interleukin-1 α and β is being developed by AbbVie for the treatment of.
Abt 981 abbott. ABT-981 or placebo will be administered as subcutaneous under the skin injections in four dosing groups. Generation and characterization of ABT-981 a dual variable domain immunoglobulin DVD-IgTM molecule. ABT-981 behaved similarly to conventional monoclonal antibodies following single or multiple doses with mean maximum serum concentrations 2 to 9 days after subcutaneous doses mean terminal half-lives of 10 to 14 days and an absolute subcutaneous bioavailability of 46.
Subjects will be administered subcutaneous injections of ABT-981.
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