ABT-494 demonstrated efficacy with a safety and tolerability profile similar to that of other JAK inhibitors. 10 rows Upadacitinib ABT-494 is a JAK1 selective inhibitor being investigated to treat rheumatoid arthritis Crohns disease ulcerative colitis.
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ABT-494 and tofacitinib inhibited common gamma chain cytokine signaling IL7 IL15 and IL21 in whole blood with similar potencies and in vivo were.
Abt 494. Upadacitinib ABT-494 is a potent orally active and selective Janus kinase 1 JAK1 inhibitor IC5043 nM. Upadacitinib ABT-494 displays approximately 74.
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